400600 L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem

400600
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₁₅N₃O₂ · 2HCl 159190-44-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400600-20MG
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          Plastic ampoule 20 mg
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          Description
          OverviewA cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC50 = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg).
          Catalogue Number400600
          Brand Family Calbiochem®
          SynonymsL-NIO, 2HCl
          References
          ReferencesMoore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
          Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.
          Product Information
          CAS number159190-44-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₇H₁₅N₃O₂ · 2HCl
          Chemical formulaC₇H₁₅N₃O₂ · 2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargeteNOS
          Primary Target IC<sub>50</sub>500 nM against endothelial nitric oxide synthase (eNOS); 2 µM against acetylcholine-induced relaxation of rat aorta rings; EC50 = 19.5 mg/kg for a dose-dependent increase in mean arterial blood pressure in the rat
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          400600

          References

          Reference overview
          Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
          Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2011 RFH
          SynonymsL-NIO, 2HCl
          DescriptionCell permeable. Approximately five times more potent as an inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM) than other arginine analogs, such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg).
          FormWhite solid
          CAS number159190-44-0
          Chemical formulaC₇H₁₅N₃O₂ · 2HCl
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Irritant
          ReferencesMoore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
          Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746.