505880 L-745,870 Trihydrochloride - CAS 158985-00-3 - Calbiochem

505880
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₉N₄Cl•3HCl 158985-00-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05880.0001
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          Glass bottle 10 mg
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          Description
          OverviewSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
          Catalogue Number505880
          Brand Family Calbiochem®
          SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
          References
          ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
          Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
          Product Information
          CAS number158985-00-3
          FormOff-white solid
          Hill FormulaC₁₈H₁₉N₄Cl•3HCl
          Chemical formulaC₁₈H₁₉N₄Cl•3HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetD₄
          Primary Target K<sub>i</sub>0.4 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Li, H. et al., 2013. J. Neurosci. 33, 3135.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
          Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          SynonymsDopamine D₄ receptor Antagonist, L-745,870 trihydrochloride, L-745870, L745870
          DescriptionSelective D4 receptor antagonist with excellent brain penetration. Displays an affinity (Ki) of 0.4 nM for human D4 receptors with >1000-fold binding selectivity over D2 and D3 receptors. Does not block agonist-induced activation of GIRK currents. It is used frequently in retinal and CNS studies of D4 modulation.
          FormOff-white solid
          CAS number158985-00-3
          Chemical formulaC₁₈H₁₉N₄Cl•3HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLi, H. et al., 2013. J. Neurosci. 33, 3135.
          Pillai, G. et al. 1998. Neuropharmacol. 337, 983.
          Kulagowski, J. et al. 1996. J. Med. Chem. 39, 1941.