422720 Sigma-AldrichL-744,832 - CAS 1177806-11-9 - Calbiochem
A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties.
More>> A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Less<<L-744,832 - CAS 1177806-11-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
Overview
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Key Specifications Table
Empirical Formula | CAS # |
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C₂₆H₄₅N₃O₆S₂ · 2HCl | 1177806-11-9 |
Pricing & Availability
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422720-5MG |
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Glass bottle | 5 mg |
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Description | |
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Overview | A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway. |
Catalogue Number | 422720 |
Brand Family | Calbiochem® |
Synonyms | (2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382 |
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Biological Information | |
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Primary Target | Farnesyltransferase (FTase) |
Purity | ≥98% by TLC |
Physicochemical Information | |
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Cell permeable | Y |
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Specifications |
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Documentation
L-744,832 - CAS 1177806-11-9 - Calbiochem SDS
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L-744,832 - CAS 1177806-11-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
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422720 |
References
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Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796. Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743. Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85. Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369. Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243. Kohl, N.E., et al. 1995. Nat. Med. 1, 792. Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302. |