420320 | KT5720 - CAS 108068-98-0 - Calbiochem

420320
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₃₁N₃O₅ 108068-98-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420320-100UG
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          Glass bottle 100 μg
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          420320-50UG
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              Plastic ampoule 50 μg
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              Description
              OverviewA potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.
              Catalogue Number420320
              Brand Family Calbiochem®
              SynonymsPKA Inhibitor VII
              References
              ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
              Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
              Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
              Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
              Product Information
              CAS number108068-98-0
              ATP CompetitiveY
              FormWhite solid
              Hill FormulaC₃₂H₃₁N₃O₅
              Chemical formulaC₃₂H₃₁N₃O₅
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              ApplicationKT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.
              Biological Information
              Primary TargetPKA
              Primary Target K<sub>i</sub>56 nM for protein kinase A
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              420320

              References

              Reference overview
              Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
              Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
              Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
              Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

              Citations

              Title
            • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-January-2010 RFH
              SynonymsPKA Inhibitor VII
              DescriptionPrepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.
              FormWhite solid
              CAS number108068-98-0
              Chemical formulaC₃₂H₃₁N₃O₅
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
              Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
              Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
              Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
              Citation
            • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.