422711 | KN-93, Water-Soluble - Calbiochem

422711
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₆H₂₉ClN₂O₄S · H₃PO₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422711-1MG
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          Glass bottle 1 mg
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          Description
          OverviewA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Also available as a 5 mM solution in H2(Cat. No. 508315).
          Catalogue Number422711
          Brand Family Calbiochem®
          References
          ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
          Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase) 2
          Primary Target K<sub>i</sub>370 nM for cam kinase 2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          422711

          References

          Reference overview
          Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-August-2008 RFH
          DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
          FormWhite solid
          Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
          Chen, C., et al. 1994. Science 266, 291.
          Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
          Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
          Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

          Related Products & Applications

          Alternative Products

          Catalog Number Description  
          422708 KN-93 - CAS 139298-40-1 - Calbiochem Show Pricing & Availability

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors