422711 KN-93, Water-Soluble - Calbiochem

422711
  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₆H₂₉ClN₂O₄S · H₃PO₄
      Description
      OverviewA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Also available as a 5 mM solution in H2(Cat. No. 508315).
      Catalogue Number422711
      Brand Family Calbiochem®
      References
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase) 2
      Primary Target K<sub>i</sub>370 nM for cam kinase 2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KN-93, Water-Soluble - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      KN-93, Water-Soluble - Calbiochem Certificates of Analysis

      TitleLot Number
      422711

      References

      Reference overview
      Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

      Brochure

      Title
      Calmodulin and Related Products Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-August-2008 RFH
      DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
      FormWhite solid
      Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
      Chen, C., et al. 1994. Science 266, 291.
      Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
      Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
      Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

      Related Products & Applications

      Alternative Products

      Catalog Number Description  
      422708 KN-93 - CAS 139298-40-1 - Calbiochem Show Pricing & Availability

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors