422706 | KN-62 - CAS 127191-97-3 - Calbiochem

422706
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₈H₃₅N₅O₆S₂ 127191-97-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      422706-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
          Catalogue Number422706
          Brand Family Calbiochem®
          Synonyms1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
          References
          ReferencesMinami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
          Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
          Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
          Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
          Product Information
          CAS number127191-97-3
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₃₈H₃₅N₅O₆S₂
          Chemical formulaC₃₈H₃₅N₅O₆S₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcam kinase 2
          Primary Target K<sub>i</sub>900 nM for rat brain CaM kinase II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          422706

          References

          Reference overview
          Minami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
          Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
          Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
          Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-November-2009 RFH
          Synonyms1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
          DescriptionA cell-permeable, reversible, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
          FormOff-white solid
          CAS number127191-97-3
          Chemical formulaC₃₈H₃₅N₅O₆S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO or Methanol (5 mg/ml). Further dilute with aqueous buffer just prior to use.
          Storage +2°C to +8°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
          Toxicity Standard Handling
          ReferencesMinami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
          Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
          Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
          Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
          Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.