420298 | K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

420298
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₂₁N₃O₅ 97161-97-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420298-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
          Catalogue Number420298
          Brand Family Calbiochem®
          References
          ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
          Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
          Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Product Information
          CAS number97161-97-2
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₂₇H₂₁N₃O₅
          Chemical formulaC₂₇H₂₁N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationK-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).
          Biological Information
          Primary TargetCaM kinase II
          Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNZ0550000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420298

          References

          Reference overview
          Cools, J., et al. 2004. Cancer Res. 64, 6385.
          Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
          Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin

          Citations

          Title
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-November-2009 RFH
          DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
          FormWhite solid
          CAS number97161-97-2
          RTECSNZ0550000
          Chemical formulaC₂₇H₂₁N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMF or DMSO (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
          Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
          Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Citation
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Related Products & Applications

          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors