420210 | Jervine - CAS 469-59-0 - Calbiochem

420210
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₃₉NO₃ 469-59-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420210-1MG
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          Plastic Bag(s) 1 mg
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          Description
          OverviewA cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.
          Catalogue Number420210
          Brand Family Calbiochem®
          Synonyms(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
          References
          ReferencesWilliams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4616.
          Cooper, M. K., et al. 2003. Nat. Genet. 33, 508.
          Mistretta, C.M., 2003. Dev. Biol. 254, 1.
          ten Berge, D., et al. 2001. Development 128, 2929.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Product Information
          CAS number469-59-0
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₇H₃₉NO₃
          Chemical formulaC₂₇H₃₉NO₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInduces cyclopia by blocking shh (Sonic Hedgehog) signaling
          Primary Target IC<sub>50</sub>~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells
          Purity≥98% by HPLC; single spot by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSWG9700000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420210

          References

          Reference overview
          Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4616.
          Cooper, M. K., et al. 2003. Nat. Genet. 33, 508.
          Mistretta, C.M., 2003. Dev. Biol. 254, 1.
          ten Berge, D., et al. 2001. Development 128, 2929.
          Cooper, M.K., et al. 1998. Science 280, 1603.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-October-2007 JSW
          Synonyms(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
          DescriptionA cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 ~500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number469-59-0
          RTECSWG9700000
          Chemical formulaC₂₇H₃₉NO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC; single spot by TLC
          SolubilityDMSO (5 mg/ml) or Ethanol (10 mg/ml). Slight warming may be required to achieve complete solubilization in ethanol.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesWilliams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 4616.
          Cooper, M. K., et al. 2003. Nat. Genet. 33, 508.
          Mistretta, C.M., 2003. Dev. Biol. 254, 1.
          ten Berge, D., et al. 2001. Development 128, 2929.
          Cooper, M.K., et al. 1998. Science 280, 1603.