504479 | JNJ 16259685 - CAS 409345-29-5 - Calbiochem

504479
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₃NO₃ 409345-29-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.04479.0001
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
          Catalogue Number504479
          Brand Family Calbiochem®
          Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
          References
          ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
          Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
          Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
          Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
          Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
          Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
          Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.
          Product Information
          CAS number409345-29-5
          FormWhite to off-white solid
          Hill FormulaC₂₀H₂₃NO₃
          Chemical formulaC₂₀H₂₃NO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetmGlu₁
          Primary Target IC<sub>50</sub>0.55 nM
          Primary Target K<sub>i</sub>0.34nM
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Lavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
          Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
          Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
          Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
          Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
          Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
          Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-November-2017 JSW
          Synonyms(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
          DescriptionAn extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.
          FormWhite to off-white solid
          CAS number409345-29-5
          Chemical formulaC₂₀H₂₃NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (25 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLavreysen, H., et al. 2004. Neuropharmacology. 47, 961.
          Steckler, T., et al. 2005. Psychopharmacology. 179, 198.
          Steckler, T., et al. 2005. Behav. Brain. Res. 164, 52.
          Mabire, D., et al. 2005. J. Med. Chem. 48, 2134.
          Fukunaga, I., et al. 2007. Br. J. Pharmacol. 151, 870.
          Knopfel, T., et al. 2007. Br. J. Pharmacol. 151, 723.
          Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther. 343, 214.