420121 | JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

420121
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₂₅NO · HCl 58753-54-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420121-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA (β-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25°C, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1].
          Catalogue Number420121
          Brand Family Calbiochem®
          Synonyms2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923
          References
          ReferencesBrown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.
          Product Information
          CAS number58753-54-1
          ATP CompetitiveY
          DeclarationSold under license of PCT Application W098/22,103.
          FormWhite crystalline solid
          Hill FormulaC₂₃H₂₅NO · HCl
          Chemical formulaC₂₃H₂₅NO · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJAK-3
          Primary Target IC<sub>50</sub>pIC50 = 7.1 against JAK3
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420121

          References

          Reference overview
          Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-July-2008 RFH
          Synonyms2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923
          DescriptionA potent, selective, and ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3) (pIC50 = 7.1). Weakly inhibits JAK1 (pIC50 = 4.4) and EGF-R (pIC50 = 5.6). Undergoes a retro-Michael breakdown to another active analog, 2-naphthylvinyl ketone (JAK3 Inhibitor V, Cat. No. 420122) (t½ = 36 min. at 25°C, pH 7.43).
          FormWhite crystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number58753-54-1
          Chemical formulaC₂₃H₂₅NO · HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (36 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesBrown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.