508507 | Isradipine - CAS 75695-93-1 - Calbiochem

508507
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₁N₃O₅ 75695-93-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08507.0001
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          Glass bottle 10 mg
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          Description
          OverviewA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number508507
          Brand Family Calbiochem®
          SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
          References
          ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
          Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
          Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
          Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
          Product Information
          CAS number75695-93-1
          FormYellow solid
          Hill FormulaC₁₉H₂₁N₃O₅
          Chemical formulaC₁₉H₂₁N₃O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCaV
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Chan, C. S. et al. 2007. Nature. 447, 1081.
          Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
          Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
          Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-January-2014 JSW
          SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
          DescriptionA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
          FormYellow solid
          CAS number75695-93-1
          Chemical formulaC₁₉H₂₁N₃O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM) or Ethanol (50 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
          Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
          Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
          Koschak, A. et al. 2001. J. Biol Chem 276, 22100.