407950 | Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

407950
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₁H₇₂O₉ 56092-81-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407950-10MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 10 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          407950-1MG
          Retrieving availability...
          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service

              Plastic ampoule 1 mg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity needs to be mulitiple of
              Upon Order Completion More Information
              You Saved ()
               
              Request Pricing
              407950-5MG
              Retrieving availability...
              Limited AvailabilityLimited Availability
              Stocked 
              Discontinued
              Limited Quantities Available
              Available
                Remaining : Will advise
                  Remaining : Will advise
                  Will advise
                  Contact Customer Service

                  Plastic ampoule 5 mg
                  Retrieving price...
                  Price could not be retrieved
                  Minimum Quantity needs to be mulitiple of
                  Upon Order Completion More Information
                  You Saved ()
                   
                  Request Pricing
                  Description
                  OverviewHighly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G1 phase in mature Burkitt lymphoma cell lines.
                  Absorption max. (280 nm, MeOH): 18,600 M-1cm-1.
                  Catalogue Number407950
                  Brand Family Calbiochem®
                  References
                  ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
                  Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
                  Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
                  Lee, H.C. 1993. J. Biol. Chem. 268, 293.
                  Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
                  Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
                  Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
                  Product Information
                  CAS number56092-81-0
                  ATP CompetitiveN
                  FormWaxy solid
                  Hill FormulaC₄₁H₇₂O₉
                  Chemical formulaC₄₁H₇₂O₉
                  ReversibleN
                  Structure formula ImageStructure formula Image
                  Applications
                  ApplicationIonomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.
                  Biological Information
                  Primary TargetMobile ion carrier for Ca2+
                  Purity≥90% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSNO0600000
                  Safety Information
                  R PhraseR: 22

                  Harmful if swallowed.
                  S PhraseS: 36

                  Wear suitable protective clothing.
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage +2°C to +8°C
                  Protect from Light Protect from light
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications

                  Documentation

                  SDS

                  Title

                  Safety Data Sheet (SDS) 

                  Certificates of Analysis

                  TitleLot Number
                  407950

                  References

                  Reference overview
                  Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
                  Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
                  Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
                  Lee, H.C. 1993. J. Biol. Chem. 268, 293.
                  Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
                  Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
                  Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

                  Brochure

                  Title
                  Calcium Metabolism and Related Products Brochure
                  Ionophores Technical Bulletin

                  Citations

                  Title
                • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
                • Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision16-April-2010 JSW
                  DescriptionHighly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+). More effective than antibiotic A23187 as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes and measurement of cytoplasmic free Ca2+. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines.
                  FormWaxy solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number56092-81-0
                  RTECSNO0600000
                  Chemical formulaC₄₁H₇₂O₉
                  Structure formulaStructure formula
                  Purity≥90% by HPLC
                  SolubilityDMSO (10 mg/ml) and Methanol (10 mg/ml)
                  Storage +2°C to +8°C
                  Protect from light
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
                  Toxicity Harmful
                  ReferencesAagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
                  Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
                  Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
                  Lee, H.C. 1993. J. Biol. Chem. 268, 293.
                  Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
                  Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
                  Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
                  Citation
                • Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
                • Related Products & Applications

                  Alternative Products

                  Catalog Number Description  
                  407952 Ionomycin, Calcium Salt, Streptomyces conglobatus - CAS 56092-82-1 - Calbiochem Show Pricing & Availability

                  Related Products

                  Catalog Number Description  
                  100105 A23187, Free Acid, Streptomyces chartreusensis - CAS 52665-69-7 - Calbiochem Show Pricing & Availability
                  205535 CA 1001 - CAS 58801-34-6 - Calbiochem Show Pricing & Availability
                  676377 Valinomycin, Streptomyces fulvissimus - CAS 2001-95-8 - Calbiochem Show Pricing & Availability

                  Categories

                  Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores