407652 | Interleukin-6, Human, Recombinant, E. coli

407652
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407652-10UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 10 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewRecombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.
          Catalogue Number407652
          Brand Family Calbiochem®
          SynonymsrhIL-6
          References
          ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
          Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
          Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
          Liu, J., et al. 1994. Cell Immunol. 155, 229.
          Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
          Product Information
          FormLyophilized
          FormulationCarrier free.
          Applications
          Biological Information
          Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407652

          References

          Reference overview
          Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
          Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
          Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
          Liu, J., et al. 1994. Cell Immunol. 155, 229.
          Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-October-2007 JSW
          SynonymsrhIL-6
          DescriptionRecombinant, human, interleukin-6 expressed in E. coli. Interleukin-6 is a protein produced by a number of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity. Stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B-cells, T-cells, and hepatocytes. Stimulates growth and inhibits constitutive protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Human sequence IL-6 is active on murine cells. 1 µg is equivalent to 7.0 x 103 WHO units.
          FormLyophilized
          FormulationCarrier free.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
          Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
          SolubilityReconstitute to 0.1-1.0 mg/ml in 100 mM acetic acid.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
          Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
          Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
          Liu, J., et al. 1994. Cell Immunol. 155, 229.
          Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.

          Related Products & Applications

          Related Products

          Catalog Number Description  
          407653 Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda Show Pricing & Availability
          407654 Interleukin-6, Mouse, Recombinant, E. coli Show Pricing & Availability

          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins