407700 | Interleukin-10, Human, Recombinant, S. frugiperda

407700
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407700-5UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service

          Plastic ampoule 5 μg
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          Description
          OverviewRecombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Blocks lipopolysaccharide induction of MMP-2 and MMP-9. Known to reduce neuronal degeneration following CNS injury by blocking glutamate-induced caspase-3 activation. Human IL-10 is also active on murine cell lines.
          Catalogue Number407700
          Brand Family Calbiochem®
          SynonymsrhIL-1αrhIL-1βrhIL-10
          References
          ReferencesBachis, A., et al. 2001. J. Neurosci. 21, 3104.
          Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
          Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
          Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
          Niro, H., et al. 1994. Int. Immunol. 6, 661.
          Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
          Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.
          Product Information
          FormLyophilized
          FormulationCarrier-free.
          Applications
          Biological Information
          Biological activityED₅₀ = 0.2-1 ng/ml as measured in a cell proliferation assay using a mouse mast cell line, MC/9.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <100 pg/μg IL-10
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze -70°C. Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407700

          References

          Reference overview
          Bachis, A., et al. 2001. J. Neurosci. 21, 3104.
          Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
          Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
          Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
          Niro, H., et al. 1994. Int. Immunol. 6, 661.
          Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
          Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-July-2008 RFH
          SynonymsrhIL-1αrhIL-1βrhIL-10
          DescriptionRecombinant, human interleukin-10 expressed in S. frugiperda insect cells. Pleiotropic cytokine that can exert either immunosuppressive or immunostimulatory effects on a variety of cell types. Potent modulator of monocyte/macrophage function. Exhibits anti-inflammatory effects by suppressing macrophage proliferation. Human IL-10 has cross-species reactivity and is active in mouse cell lines.
          FormLyophilized
          FormulationCarrier-free.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: <100 pg/μg IL-10
          Biological activityED₅₀ = 0.2-1 ng/ml as measured in a cell proliferation assay using a mouse mast cell line, MC/9.
          SolubilityReconstitute in sterile water or buffer to a final concentration of 0.1-1 mg/ml as stock solution. Further dilute in buffer such as PBS, 1% BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze -70°C. Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesBachis, A., et al. 2001. J. Neurosci. 21, 3104.
          Fortunato, S.J., et al. 2001. Obstet. Gynecol. 98, 284.
          Fleming, S.D., et al. 1996. J. Immunol. 156, 1143.
          Wang, C.Q., et al. 1996. J. Cell Physiol. 166, 305.
          Niro, H., et al. 1994. Int. Immunol. 6, 661.
          Moore, K., et al. 1993. Annu. Rev. Immunol. 11, 165.
          Vieira, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 1172.