407245 | Insulin-Like Growth Factor-II, Human, Recombinant, E. coli

407245
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥97% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407245-50UG
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      Discontinued
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      Available
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          Plastic ampoule 50 μg
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          Description
          OverviewRecombinant, human insulin-like growth factor-II expressed in E. coli. Its actions are similar to IGF-1 (Cat. No. 407240). Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
          Catalogue Number407245
          Brand Family Calbiochem®
          SynonymsrhIGF-II
          References
          ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
          Hill, P.A., et al. 1995. Endocrinology 136, 124.
          Nielson, F.C., et al. 1995. Nature 377, 358.
          LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
          Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
          Rotwein, P. 1991. Growth Factors 5, 3.
          Product Information
          CAS number67763-97-7
          FormLyophilized
          FormulationLyophilized from sterile-filtered acetic acid.
          Applications
          Biological Information
          Biological activityED₅₀ = 5-10 ng/ml
          Purity≥97% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: <1 EU/µg IGF-II
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSNM8906000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407245

          References

          Reference overview
          Feldser, D., et al. 1999. Cancer Res. 59, 3915.
          Hill, P.A., et al. 1995. Endocrinology 136, 124.
          Nielson, F.C., et al. 1995. Nature 377, 358.
          LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
          Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
          Rotwein, P. 1991. Growth Factors 5, 3.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          SynonymsrhIGF-II
          DescriptionRecombinant, human insulin-like growth factor-II expressed in E. coli. A growth-promoting peptide that is structurally related to insulin. IGF-II shares about 76% sequence identity with IGF-I and ~50% with pro-insulin. Its actions are similar to IGF-I (Cat. No. 407240). IGF-II is a nonglycosylated, single chain peptide of 67 amino acids. Plays an important role in fetal development. Stimulates muscle and bone cell proliferation and differentiation.
          FormLyophilized
          FormulationLyophilized from sterile-filtered acetic acid.
          CAS number67763-97-7
          RTECSNM8906000
          Purity≥97% by SDS-PAGE
          ContaminantsEndotoxin: <1 EU/µg IGF-II
          Biological activityED₅₀ = 5-10 ng/ml
          SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA. Avoid using buffers near the isoelectric point (6.5).
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Toxicity Standard Handling
          Merck USA index14, 4986
          ReferencesFeldser, D., et al. 1999. Cancer Res. 59, 3915.
          Hill, P.A., et al. 1995. Endocrinology 136, 124.
          Nielson, F.C., et al. 1995. Nature 377, 358.
          LeRoith, D., and Roberts, C.R., Jr. 1993. Ann. N.Y. Acad. Sci. 692, 1.
          Lowe, W.L. 1991. In Insulin-Like Growth Factors: Molecular and Cellular Aspects (LeRoith, D., Ed.) CRC Press Inc., Boca Raton p. 49.
          Rotwein, P. 1991. Growth Factors 5, 3.