534342 InhA Inhibitor, NITD-916 - Calbiochem

534342
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₂₅NO₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.34342.0001
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          Glass bottle 25 mg
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          Description
          OverviewA cell-permeable, orally available, highly lipophilic 4-hydroxy-2-pyridone derivative that directly binds to the enoyl-substrate binding pocket of Mycobaterial enoyl reductase inhA in an NADH-dependent manner and inhibits its activity (IC50 = 570 nM). Shown to be about 5 to 8 times more potent ((MIC50 = 40 to 160 nM in multi-drug resistant strains of Mycobacterium) than isoniazid (MIC50 = 330 nM) and PA-824 (MIC50 = 400 nM). Exhibits in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. Exhibits low to moderate metabolic clearance in mouse and human hepatic microsomes. Suggested to inhibit the fatty acid elongation step that blocks the biosynthesis of mycolic acids and weakens the cell wall mycolyl-arabinogalactan-peptidoglycan complex, and ultimately lysis of Mycobacterium.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number534342
          Brand Family Calbiochem®
          Synonyms6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one , Enoyl-acyl Carrier Protein Reductase Inhibitor, NITD-916, Enoyl-ACP reductase, NITD-916
          References
          ReferencesManjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.
          Product Information
          FormWhite solid
          Hill FormulaC₂₀H₂₅NO₂
          Chemical formulaC₂₀H₂₅NO₂
          Applications
          Biological Information
          Primary TargetInhA
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Regulatory Review
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InhA Inhibitor, NITD-916 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Manjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-August-2017 JSW
          Synonyms6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one , Enoyl-acyl Carrier Protein Reductase Inhibitor, NITD-916, Enoyl-ACP reductase, NITD-916
          DescriptionA cell-permeable, orally available, highly lipophilic 4-hydroxy-2-pyridone derivative that directly binds to the enoyl-substrate binding pocket of Mycobaterial enoyl reductase inhA in an NADH-dependent manner and inhibits its activity (IC50 = 570 nM). Shown to be about 5 to 8 times more potent ((MIC50 = 40 to 160 nM in multi-drug resistant strains of Mycobacterium) than isoniazid (MIC50 = 330 nM) and PA-824 (MIC50 = 400 nM). Exhibits in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection. Exhibits low to moderate metabolic clearance in mouse and human hepatic microsomes. Suggested to inhibit the fatty acid elongation step that blocks the biosynthesis of mycolic acids and weakens the cell wall mycolyl-arabinogalactan-peptidoglycan complex, and ultimately lysis of Mycobacterium.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₂₅NO₂
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Regulatory Review
          ReferencesManjunatha, U., et al. 2015. Sci. Trans. Med. 7, 269.