402085 | Indirubin-3ʹ-monoxime - CAS 160807-49-8 - Calbiochem

402085
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₁N₃O₂ 160807-49-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      402085-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC50 = 22 nM, 180 nM, and 100 nM, respectively). Inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle. Inhibits Tau phosphorylation in vitro and in vivo at Alzheimer’s disease-specific sites. Also reported to inhibit the in vivo phosphorylation of DARPP-32 by Cdk5 on Thr75.
          Catalogue Number402085
          Brand Family Calbiochem®
          References
          ReferencesBain, J., et al. 2003. Biochem. J. 371, 199.
          Leclerc, S., et al. 2000. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
          Product Information
          CAS number160807-49-8
          ATP CompetitiveY
          FormDark red solid
          Hill FormulaC₁₆H₁₁N₃O₂
          Chemical formulaC₁₆H₁₁N₃O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGsk-3β
          Primary Target IC<sub>50</sub>22 nM, 180 nM, and 100 nM against GSK-3β, Cdk1, and Cdk5, respectively
          Purity≥ 98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          402085

          References

          Reference overview
          Bain, J., et al. 2003. Biochem. J. 371, 199.
          Leclerc, S., et al. 2000. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-December-2009 RFH
          DescriptionA potent cell-permeable, reversible, and ATP-compatible inhibitor of glycogen synthase kinase-3β (IC50 = 22 nM) and cyclin-dependent kinases (IC50 = 180 nM for Cdk1 and 100 nM for Cdk5). Inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle. Inhibits Tau phosphorylation in vitro and in vivo at Alzheimer's disease-specific sites. Also reported to inhibit the in vivo phosphorylation of DARPP-32 by Cdk5 on Thr75.
          FormDark red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number160807-49-8
          Chemical formulaC₁₆H₁₁N₃O₂
          Structure formulaStructure formula
          Purity≥ 98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesBain, J., et al. 2003. Biochem. J. 371, 199.
          Leclerc, S., et al. 2000. J. Biol. Chem. 276, 251.
          Hoessel, R., et al. 1999. Nat. Cell Biol. 1, 60.