402088 | Indirubin-3ʹ-monoxime-5-sulphonic Acid - CAS 331467-05-1 - Calbiochem

402088
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₁N₃O₅S 331467-05-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      402088-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, reversible, and selective inhibitor of Cdk1 (IC50 = 5 nM) and Cdk5 (IC50 = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM). The inhibition is competitive with respect to ATP.
          Catalogue Number402088
          Brand Family Calbiochem®
          References
          ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
          Product Information
          CAS number331467-05-1
          ATP CompetitiveY
          FormDark red solid
          Hill FormulaC₁₆H₁₁N₃O₅S
          Chemical formulaC₁₆H₁₁N₃O₅S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCDK1
          Primary Target IC<sub>50</sub>5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          402088

          References

          Reference overview
          Leclerc, S., et al. 2001. J. Biol. Chem. 276, 251.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          DescriptionA highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50 = 5 nM for CDK1; IC50 = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 80 nM).
          FormDark red solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number331467-05-1
          Chemical formulaC₁₆H₁₁N₃O₅S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesLeclerc, S., et al. 2001. J. Biol. Chem. 276, 251.