509721 | InSolution™ Vitamin D3, 1α, 25-Dihydroxy- - Calbiochem

509721
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₇H₄₄O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.09721.0001
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      Limited AvailabilityLimited Availability
      Stocked 
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      Available
        Remaining : Will advise
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          Glass bottle 50 μg
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          Description
          Catalogue Number509721
          Brand Family Calbiochem®
          Synonyms1,25-(OH)₂-D₃
          References
          ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Mathieu, C., et al. 1994. Diabetologica 37, 552.
          Thomasset, M. 1994. Pathol. Biol. 42, 163.
          Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
          Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
          Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
          Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
          Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
          Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
          DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
          Product Information
          FormLiquid
          FormulationA 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.
          Hill FormulaC₂₇H₄₄O₃
          Chemical formulaC₂₇H₄₄O₃
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary Targetvitamin D receptor
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Mathieu, C., et al. 1994. Diabetologica 37, 552.
          Thomasset, M. 1994. Pathol. Biol. 42, 163.
          Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
          Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
          Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
          Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
          Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
          Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
          DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2014 JSW
          Synonyms1,25-(OH)₂-D₃
          DescriptionActive hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
          FormLiquid
          FormulationA 1 mM (50 ug/112 µL) solution of Vitamin D3, 1α, 25-Dihydroxy- (Cat. No. 679101) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₇H₄₄O₃
          Purity≥99% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSemizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
          Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
          Mathieu, C., et al. 1994. Diabetologica 37, 552.
          Thomasset, M. 1994. Pathol. Biol. 42, 163.
          Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
          Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
          Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
          Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
          Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
          Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
          DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.