508319 | InSolution™ TNP-ATP - Calbiochem

508319
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₂N₈O₁₉P₃Na₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08319.0001
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          Glass bottle 1 mg
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          Description
          OverviewA highly potent, non-competitive antagonist of purinergic P2X3 receptor (IC50 = 900 pM) and blocks a,b-MeATP evoked responses in rat mesenteric artery smooth muscle cells. Reportedly binds to an allosteric site on the large extracellular region of the receptor. Also, blocks P2X1 and P2X2/3 receptors at higher concentration (IC50 = 6 and 7 nM, respectively). Does not affect P2X2, P2X4, or P2X7 receptors in any significant manner (IC50 = 2.0, 15.2, and 30 µM, respectively). Shown to reduce resiniferatoxin- induced neuropathic pain in a dose-dependent manner. Also used as a fluorescent probe for ATP binding.
          Catalogue Number508319
          Brand Family Calbiochem®
          Synonyms2ʹ,3ʹ-O-(2,4,6-Trinitrophenyl) adenosine 5ʹ-triphosphate Sodium Salt, Purinergic P2X3 Receptor Antagonist, TNP-ATP, Purinergic Receptor Antagonist, TNP-ATP, Fluorescent ATP Analog, TNP-ATP
          References
          ReferencesHsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
          Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
          Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.
          Product Information
          FormRed liquid
          Hill Formula C₁₆H₁₂N₈O₁₉P₃Na₄
          Chemical formulaC₁₆H₁₂N₈O₁₉P₃Na₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target IC<sub>50</sub>900 pM
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          References

          Reference overview
          Hsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
          Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
          Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-October-2013 JSW
          Synonyms2ʹ,3ʹ-O-(2,4,6-Trinitrophenyl) adenosine 5ʹ-triphosphate Sodium Salt, Purinergic P2X3 Receptor Antagonist, TNP-ATP, Purinergic Receptor Antagonist, TNP-ATP, Fluorescent ATP Analog, TNP-ATP
          DescriptionA highly potent, non-competitive antagonist of purinergic P2X3 receptor (IC50 = 900 pM) and blocks a,b-MeATP evoked responses in rat mesenteric artery smooth muscle cells. Reportedly binds to an allosteric site on the large extracellular region of the receptor. Also, blocks P2X1 and P2X2/3 receptors at higher concentration (IC50 = 6 and 7 nM, respectively). Does not affect P2X2, P2X4, or P2X7 receptors in any significant manner (IC50 = 2.0, 15.2, and 30 µM, respectively). Shown to reduce resiniferatoxin- induced neuropathic pain in a dose-dependent manner. Also used as a fluorescent probe for ATP binding.
          FormRed liquid
          Chemical formulaC₁₆H₁₂N₈O₁₉P₃Na₄
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Solubility10 mM Phosphate Buffer
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHsieh, Y.L., et al. 2012. Exp. Neurol. 235, 316.
          Virginio, C., et al. 1998. Mol. Pharmacol. 53, 969.
          Hiratsuka, T. et, al. 1975. J. Biochem. 78, 1135.