509612 | InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem

509612
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₃₇N₅O₅ 187034-31-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.09612.0001
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          Glass bottle 1 mg
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          Description
          Catalogue Number509612
          Brand Family Calbiochem®
          References
          ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
          Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
          Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
          Parvathy, S., et al. 1997. Biochem. J. 327, 37.
          Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
          Product Information
          CAS number187034-31-7
          FormLiquid
          FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
          Hill FormulaC₁₉H₃₇N₅O₅
          Chemical formulaC₁₉H₃₇N₅O₅
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
          Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
          Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
          Parvathy, S., et al. 1997. Biochem. J. 327, 37.
          Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-April-2014 JSW
          DescriptionA hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
          FormLiquid
          FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number187034-31-7
          Chemical formulaC₁₉H₃₇N₅O₅
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
          Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
          Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
          Parvathy, S., et al. 1997. Biochem. J. 327, 37.
          Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.