569396 InSolution™ Staurosporine, Streptomyces sp.

569396
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₆N₄O₃ 62996-74-1
      Description
      Catalogue Number569396
      Brand Family Calbiochem®
      SynonymsPKA Inhibitor II, MLCK Inhibitor I
      References
      ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
      Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
      Bruno, S., et al. 1992. Cancer Res. 52, 470.
      Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
      Vitale, M.L., et al. 1992. Neuroscience 51, 463.
      Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
      Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
      Product Information
      CAS number62996-74-1
      ATP CompetitiveY
      FormLiquid
      FormulationA 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.
      Hill FormulaC₂₈H₂₆N₄O₃
      Chemical formulaC₂₈H₂₆N₄O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      ApplicationInSolution™ Staurosporine, Streptomyces sp. CAS 62996-74-1, is provided as a 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO
      Biological Information
      Primary TargetPKA
      Primary Target IC<sub>50</sub>7 nM, 20 nM, 1.3 nM, 700 pM, 8.5 nM, against protein kinase A , CaM kinase, myosin light chain kinase, protein kinase C, and protein kinase G, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Staurosporine, Streptomyces sp. SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Staurosporine, Streptomyces sp. Certificates of Analysis

      TitleLot Number
      569396

      References

      Reference overview
      Couldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
      Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
      Bruno, S., et al. 1992. Cancer Res. 52, 470.
      Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
      Vitale, M.L., et al. 1992. Neuroscience 51, 463.
      Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
      Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.

      Citations

      Title
    • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-July-2008 JSW
      SynonymsPKA Inhibitor II, MLCK Inhibitor I
      DescriptionA potent, cell-permeable broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
      FormLiquid
      FormulationA 1 mM (100 µg/214 µl) solution of Staurosporine (Cat. No. 569397) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number62996-74-1
      Chemical formulaC₂₈H₂₆N₄O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage ≤ -70°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-70°C).
      Toxicity Irritant
      ReferencesCouldwell, W.T., et al. 1994. FEBS Lett. 345, 43.
      Nishimura, H. and Simpson, I.A. 1994. Biochem. J. 302, 271.
      Bruno, S., et al. 1992. Cancer Res. 52, 470.
      Kiss, Z. and Deli, E. 1992. Biochem. J. 288, 853.
      Vitale, M.L., et al. 1992. Neuroscience 51, 463.
      Hoffman, R. and Newland, E.S. 1991. Cancer Chemotherap. Pharmacol. 28, 102.
      Oka, S., et al. 1986. Agric. Biol. Chem. 50, 2723.
      Citation
    • Siva Kumar Kolluri, et al. (2005) The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Procedings of the National Academy of Science 102, 2525-2530.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.