565784 InSolution™ γ-Secretase Inhibitor IX - Calbiochem

565784
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₆F₂N₂O₄

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      565784-10MG
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          Plastic ampoule 10 mg
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          565784-5MG
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              Glass bottle 5 mg
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              Description
              Catalogue Number565784
              Brand Family Calbiochem®
              SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
              References
              ReferencesOddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
              Product Information
              ATP CompetitiveN
              FormClear colorless liquid
              FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
              Hill FormulaC₂₃H₂₆F₂N₂O₄
              Chemical formulaC₂₃H₂₆F₂N₂O₄
              Hygroscopic Hygroscopic
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targettotal
              Primary Target IC<sub>50</sub>115 nM, 200 nM against Aβtotal, Aβ42, respectively
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Irritant
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              InSolution™ γ-Secretase Inhibitor IX - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              InSolution™ γ-Secretase Inhibitor IX - Calbiochem Certificates of Analysis

              TitleLot Number
              565784

              References

              Reference overview
              Oddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

              Citations

              Title
            • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
            • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
            • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision28-January-2013 JSW
              SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
              DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
              FormClear colorless liquid
              FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
              Intert gas (Yes/No) Packaged under inert gas
              Chemical formulaC₂₃H₂₆F₂N₂O₄
              Structure formulaStructure formula
              Purity≥95% by HPLC
              Storage +2°C to +8°C
              Hygroscopic
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
              Toxicity Irritant
              ReferencesOddo, S., et al. 2004. Neuron 43, 321.
              Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
              Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
              Citation
            • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
            • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
            • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.