557521 InSolution™ Ro-31-8220 - Calbiochem

557521
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability

      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₅H₂₃N₅O₂S • CH₃SO₃H

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      557521-500UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Plastic ampoule 500 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          Catalogue Number557521
          Brand Family Calbiochem®
          Synonyms3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
          References
          Product Information
          ATP CompetitiveY
          FormClear orange-brown liquid
          FormulationA 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H₂O.
          Hill FormulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
          Chemical formulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>10 nM against protein kinase C (PKC); 6.8 nM against GSK-3 in primary adipocytes
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Ro-31-8220 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Ro-31-8220 - Calbiochem Certificates of Analysis

          TitleLot Number
          557521

          Citations

          Title
        • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2008 RFH
          Synonyms3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate
          DescriptionA competitive, selective inhibitor for protein kinase C (IC50 = 10 nM) over protein kinase A (IC50 = 900 nM), Ca2+/calmodulin-dependent protein kinase (IC50 = 17 µM) and phosphorylase protein kinase. Inhibits TPA induced p47 phosphorylation in platelets (IC50 = 700 nM). Also inhibits CD3 downregulation in T cells (IC50 = 500 nM).
          FormClear orange-brown liquid
          FormulationA 5 mM (500 µg/181 µl) solution of Ro-31-8220 (Cat. No. 557520) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₂₃N₅O₂S • CH₃SO₃H
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          Citation
        • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.