555552 InSolution™ Rho Kinase Inhibitor - Calbiochem

555552
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₂₁N₃O₂S • 2HCl

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      555552-500UG
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          Plastic ampoule 500 μg
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          Description
          Catalogue Number555552
          Brand Family Calbiochem®
          References
          ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
          Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
          Product Information
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
          Hill FormulaC₁₆H₂₁N₃O₂S • 2HCl
          Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetROCK
          Primary Target K<sub>i</sub>1.6 nM against Rho-associated kinase (ROCK)
          Purity≥95% by HPLC
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ Rho Kinase Inhibitor - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Rho Kinase Inhibitor - Calbiochem Certificates of Analysis

          TitleLot Number
          555552

          References

          Reference overview
          Ikenoya, M., et al. 2002. J. Neurochem. 81, 9.
          Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-September-2008 RFH
          DescriptionA cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki = 630 nM for PKA, 9.27 µM for PKC, and 10.1 µM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50 = 2.5 µM). Reported to be a more potent and selective inhibitor than Y-27632 (Cat. No. 688000 & 688001).
          FormLiquid
          FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          Concentration Label Please refer to vial label for lot-specific concentration
          Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Harmful
          ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
          Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.