508227 | InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

508227
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₇H₅₁NO₁₄ 33069-62-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08227.0001
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          Glass bottle 10 mg
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          Description
          Catalogue Number508227
          Brand Family Calbiochem®
          SynonymsTAXOL® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester
          References
          ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
          Product Information
          CAS number33069-62-4
          FormLiquid
          FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
          Hill FormulaC₄₇H₅₁NO₁₄
          Chemical formulaC₄₇H₅₁NO₁₄
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetmicrotubules
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Derry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-December-2013 JSW
          SynonymsTAXOL® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester
          DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
          FormLiquid
          FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number33069-62-4
          Chemical formulaC₄₇H₅₁NO₁₄
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
          Toxicity Standard Handling
          ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
          Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
          Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
          Hornback, N.B., et al. 1994. In Vivo 8, 819.
          Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
          Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
          Ding, A.H., et al. 1990. Science 248, 370.
          Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
          Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.