528101 | InSolution™ PI-103

528101
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₉H₁₆N₄O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      528101-2MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 2 mg
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          Description
          Catalogue Number528101
          Brand Family Calbiochem®
          SynonymsPI 3-K Inhibitor V, mTOR Inhibitor V
          References
          ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.
          Product Information
          FormLiquid
          FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
          Hill FormulaC₁₉H₁₆N₄O₃
          Chemical formulaC₁₉H₁₆N₄O₃
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528101

          References

          Reference overview
          Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-December-2008 JSW
          SynonymsPI 3-K Inhibitor V, mTOR Inhibitor V
          DescriptionA cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
          FormLiquid
          FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₉H₁₆N₄O₃
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
          Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
          Knight, Z.A., et al. 2006. Cell 125, 733.