495624 | InSolution™ Olomoucine - Calbiochem

495624
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅H₁₈N₆O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      495624-5MG
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          Plastic ampoule 5 mg
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          Description
          Catalogue Number495624
          Brand Family Calbiochem®
          References
          Product Information
          ATP CompetitiveY
          FormLiquid
          FormulationA 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495620) in DMSO.
          Hill FormulaC₁₅H₁₈N₆O
          Chemical formulaC₁₅H₁₈N₆O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetp34cdk1/cyclin B
          Primary Target IC<sub>50</sub>100 nM-100 µM against p34cdk1/cyclin B
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          495624
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-August-2008 RFH
          DescriptionA purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 >1 mM) and p40cdk6/cyclin D3 (IC50 >250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
          FormLiquid
          FormulationA 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495620) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅H₁₈N₆O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Irritant