487929 InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem

487929
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O₃S 31430-18-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      487929-10MG
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          Glass bottle 10 mg
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          Description
          OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
          Catalogue Number487929
          Brand Family Calbiochem®
          SynonymsMethyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934
          References
          ReferencesPark, H., et al. 2012. Chem. Med. Chem. 7, 53.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Product Information
          CAS number31430-18-9
          FormLiquid
          FormulationA 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
          Hill FormulaC₁₄H₁₁N₃O₃S
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMicrotubules
          Secondary targetCertain kinases
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          487929

          References

          Reference overview
          Park, H., et al. 2012. Chem. Med. Chem. 7, 53.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-December-2012 JSW
          SynonymsMethyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934
          DescriptionInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM). The solid form of this compound (Cat. No. 487928) is also available.
          FormLiquid
          FormulationA 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number31430-18-9
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
          Toxicity Irritant
          ReferencesPark, H., et al. 2012. Chem. Med. Chem. 7, 53.
          Bunz, F., et al. 1998. Science 282, 1497.
          Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
          Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
          Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.