474788 | InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem

474788
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₆H₄₁N₃O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      474788-10MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 10 mg
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          Description
          OverviewPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
          Catalogue Number474788
          Brand Family Calbiochem®
          SynonymsProteasome Inhibitor XI
          Application Data
          References
          ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.
          Product Information
          FormLiquid
          FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
          Hill FormulaC₂₆H₄₁N₃O₅
          Chemical formulaC₂₆H₄₁N₃O₅
          ReversibleY
          Applications
          Biological Information
          Primary Target K<sub>i</sub>Ki = 4 nM for proteasomal inhibition
          Secondary targetIKK
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Leu-Leu-Leu-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 11-22

          Highly flammable.
          Harmful if swallowed.
          S PhraseS: 16-7

          Keep away from sources of ignition - No Smoking.
          Keep container tightly closed.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Flammable
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage ≤ -70°C
          Protect from Light Protect from light
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          474788

          References

          Reference overview
          Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-March-2012 JSW
          SynonymsProteasome Inhibitor XI
          Application Data
          DescriptionPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.
          FormLiquid
          FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₆H₄₁N₃O₅
          Peptide SequenceZ-Leu-Leu-Leu-CHO
          Purity≥95% by HPLC
          Storage ≤ -70°C
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
          Toxicity Flammable
          ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
          Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
          Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
          Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
          Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
          Wiertz, E.J., et al. 1996. Cell 84, 769.
          Jensen, T.J., et al. 1995. Cell 83, 129.
          Read, M.A., et al. 1995. Immunity 2, 493.
          Rock, K.L., et al. 1994. Cell 78, 761.