440204 | InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem

440204
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₇NO₃ 154447-36-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      440204-1MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          Contact Customer Service

          Plastic ampoule 1 mg
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          Description
          Catalogue Number440204
          Brand Family Calbiochem®
          Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
          References
          ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
          Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
          Cardone, M.H., et al. 1998. Science 282, 1318.
          Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
          Yano, H., et al. 1995. Biochem. J. 312, 145.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Product Information
          CAS number154447-36-6
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
          Hill FormulaC₁₉H₁₇NO₃
          Chemical formulaC₁₉H₁₇NO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).
          Biological Information
          Primary Targetphosphatidylinositol 3-kinase
          Primary Target IC<sub>50</sub>1.4 µM against phosphatidylinositol 3-kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          440204

          References

          Reference overview
          Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
          Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
          Cardone, M.H., et al. 1998. Science 282, 1318.
          Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
          Yano, H., et al. 1995. Biochem. J. 312, 145.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Citations

          Title
        • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
        • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
        • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
        • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-August-2008 RFH
          Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
          FormLiquid
          FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number154447-36-6
          Chemical formulaC₁₉H₁₇NO₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
          Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
          Cardone, M.H., et al. 1998. Science 282, 1318.
          Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
          Yano, H., et al. 1995. Biochem. J. 312, 145.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Citation
        • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
        • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
        • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
        • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
        • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.