420297 | InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

420297
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₂₁N₃O₅ 97161-97-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420297-100UG
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          Plastic ampoule 100 μg
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          Description
          Catalogue Number420297
          Brand Family Calbiochem®
          References
          ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
          Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
          Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
          Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
          Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
          Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Product Information
          CAS number97161-97-2
          ATP CompetitiveY
          FormLiquid
          FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
          Hill FormulaC₂₇H₂₁N₃O₅
          Chemical formulaC₂₇H₂₁N₃O₅
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCaM kinase II
          Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420297

          References

          Reference overview
          Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
          Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
          Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
          Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
          Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
          Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

          Brochure

          Title
          Calmodulin and Related Products Technical Bulletin

          Citations

          Title
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-July-2008 JSW
          DescriptionA cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 17 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), and protein kinase G (Ki = 20 nM). Also acts as a potent inhibitor (IC50 = 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.
          FormLiquid
          FormulationA 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number97161-97-2
          Chemical formulaC₂₇H₂₁N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
          Toxicity Irritant
          ReferencesChin, L.S., et al. 1999. Cancer Invest. 17, 391.
          Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
          Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
          Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
          Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
          Tapley, P., et al. 1992. Oncogene 7, 371.
          Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
          Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
          Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Citation
        • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
        • Related Products & Applications

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors