420128 | InSolution™ JNK Inhibitor II - Calbiochem

420128
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₈N₂O

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420128-5MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 5 mg
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          Description
          Catalogue Number420128
          Brand Family Calbiochem®
          References
          ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Product Information
          ATP CompetitiveY
          FormYellowish brown liquid
          FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
          Hill FormulaC₁₄H₈N₂O
          Chemical formulaC₁₄H₈N₂O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetJNK 1, JNK 2, JNK 3
          Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420128

          References

          Reference overview
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-July-2008 RFH
          DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
          FormYellowish brown liquid
          FormulationA 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₄H₈N₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
          Toxicity Irritant
          ReferencesBennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.