420097 | InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

420097
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆FN₃O 457081-03-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      420097-500UG
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          Plastic ampoule 500 μg
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          Description
          Catalogue Number420097
          Brand Family Calbiochem®
          Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
          References
          ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
          Product Information
          CAS number457081-03-7
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
          Hill FormulaC₁₈H₁₆FN₃O
          Chemical formulaC₁₈H₁₆FN₃O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
          Biological Information
          Primary Targetmurine JAK1
          Primary Target IC<sub>50</sub>15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
          Primary Target K<sub>i</sub> 5 nM against JAK3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          420097

          References

          Reference overview
          Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-February-2009 JSW
          Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
          DescriptionA potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
          FormLiquid
          FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number457081-03-7
          Chemical formulaC₁₈H₁₆FN₃O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Irritant
          ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.