505378 | InSolution™ IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem

505378
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₂₉N₅OS 873225-46-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05378.0001
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          Glass bottle 500 μg
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          Description
          OverviewA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
          Catalogue Number505378
          Brand Family Calbiochem®
          SynonymsIKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
          References
          ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
          Product Information
          CAS number873225-46-8
          FormLiquid
          FormulationA 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.
          Hill FormulaC₂₈H₂₉N₅OS
          Chemical formulaC₂₈H₂₉N₅OS
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetIKK-2, IKK complex, and IKK-1
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-December-2013 JSW
          SynonymsIKK 16, (4-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone, InSolution IKK Inhibitor VII
          DescriptionA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
          FormLiquid
          FormulationA 10 mM (500 µg/103 µL) sterile-filtered solution of IKK Inhibitor VII (Cat. No. 401486) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number873225-46-8
          Chemical formulaC₂₈H₂₉N₅OS
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.