371962 | InSolution™ H-89, Dihydrochloride - Calbiochem

371962
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₀H₂₀BrN₃O₂S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      371962-1MG
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          Plastic ampoule 1 mg
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          Description
          Catalogue Number371962
          Brand Family Calbiochem®
          SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
          References
          ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
          Davies, S.P. et al. 2000. Biochem. J. 351, 95.
          de Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
          Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
          Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
          Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
          Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
          Hill FormulaC₂₀H₂₀BrN₃O₂S
          Chemical formulaC₂₀H₂₀BrN₃O₂S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
          Biological Information
          Primary TargetPKA
          Primary Target K<sub>i</sub>48 nM against protein kinase A
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          371962

          References

          Reference overview
          Leemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
          Davies, S.P. et al. 2000. Biochem. J. 351, 95.
          de Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
          Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
          Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
          Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
          Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-September-2007 JSW
          SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
          DescriptionA solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 µM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 µM), protein kinase C (Ki = 31.7 µM), casein kinase I (Ki = 38.3 µM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 µM) by blocking the action of Rho kinase II.
          FormLiquid
          FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₀H₂₀BrN₃O₂S
          Structure formulaStructure formula
          Purity≥99% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
          Davies, S.P. et al. 2000. Biochem. J. 351, 95.
          de Rooij, J., et al. 1998. Nature. 396, 474.
          Kawasaki, H., et al. 1998. Science. 282, 2275.
          Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
          Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
          Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
          Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
          Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.