361552 | InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

361552
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₀BrN₃O₂ 667463-62-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      361552-500UG
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          Plastic ampoule 500 μg
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          Description
          Catalogue Number361552
          Brand Family Calbiochem®
          References
          ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Product Information
          CAS number667463-62-9
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
          Hill FormulaC₁₆H₁₀BrN₃O₂
          Chemical formulaC₁₆H₁₀BrN₃O₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGSK-3α/β
          Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          361552

          References

          Reference overview
          Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2008 JSW
          DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
          FormLiquid
          FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number667463-62-9
          Chemical formulaC₁₆H₁₀BrN₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Carcinogenic / Teratogenic
          ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
          Sato, N., et al. 2004. Nat. Med. 10, 55.
          Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors