239807 | InSolution™ Cyclopamine-KAAD - Calbiochem

239807
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₄H₆₃Nl₃O₄

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239807-50UG
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      Stocked 
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      Available
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          Glass bottle 50 μg
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          Description
          OverviewA cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available.
          Catalogue Number239807
          Brand Family Calbiochem®
          Synonyms3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
          References
          ReferencesSiegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Product Information
          FormLiquid
          FormulationA 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO.
          Hill FormulaC₄₄H₆₃Nl₃O₄
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          ApplicationInSolution™ Cyclopamine-KAAD, CAS 306387-90-6, is a 1 mM solution in DMSO. A cell-permeable, potent analog of Cyclopamine. Inhibits Hedgehog signaling (IC50 = 20 nM) with lower toxicity.
          Biological Information
          Primary TargetSmoA1
          Purity≥70% by HPLC (sum of two isomers)
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36/37/39

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239807

          References

          Reference overview
          Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          Synonyms3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
          DescriptionA cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available.
          FormLiquid
          FormulationA 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Structure formulaStructure formula
          Purity≥70% by HPLC (sum of two isomers)
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
          Toxicity Irritant
          ReferencesSiegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
          Watkins, D.N., et al. 2003. Nature 422, 313.
          Berman, D.M., et al. 2002. Science 297, 1559.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Taipale, J., et al. 2000. Nature 406, 1005.