239765 | InSolution™ Cycloheximide - CAS 66-81-9 - Calbiochem

239765
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₂₃NO₄ 66-81-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239765-1ML
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          Alu drum 1 ml
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          Description
          Catalogue Number239765
          Brand Family Calbiochem®
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Product Information
          CAS number66-81-9
          FormLiquid
          FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Applications
          ApplicationInSolution™ Cycloheximide, CAS 66-81-9, is a 100 mg/ml, sterile-filtered solution of Cycloheximide (Cat. No. 239763) in DMSO. An antifungal antibiotic that inhibits protein synthesis in eukaryotes.
          Biological Information
          Primary TargethFKBP12
          Primary Target K<sub>i</sub>3.4 µM
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMA4375000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239765

          References

          Reference overview
          Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.

          Citations

          Title
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-June-2008 RFH
          DescriptionA convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
          FormLiquid
          FormulationA 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
          Intert gas (Yes/No) Packaged under inert gas
          CAS number66-81-9
          RTECSMA4375000
          Chemical formulaC₁₅H₂₃NO₄
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Obrig, T.G., et al. 1971. J. Biol. Chem. 246, 174.
          Pestka, S. 1971. Annu. Rev. Microbiol. 25, 487.
          Citation
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.