235427 | InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

235427
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₉₄H₁₅₈N₂₀O₂₇

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      235427-1MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Glass bottle 1 mg
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          Description
          Catalogue Number235427
          Brand Family Calbiochem®
          SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
          References
          ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
          Hill FormulaC₉₄H₁₅₈N₂₀O₂₇
          Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary Targetcaspase-3
          Primary Target IC<sub>50</sub>200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          235427

          References

          Reference overview
          Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.

          Citations

          Title
        • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-March-2008 JSW
          SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
          DescriptionA cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
          FormLiquid
          FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
          Purity≥90% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
          Toxicity Irritant
          ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
          Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
          Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
          Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Tewari, M., et al. 1995. Cell 81, 801.
          Lazebnik, Y.A., et al. 1994. Nature 371, 346.
          Citation
        • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.