218705 | InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem

218705
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₁₈N₄O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218705-1MG
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      Stocked 
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      Available
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          Plastic ampoule 1 mg
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          Description
          Catalogue Number218705
          Brand Family Calbiochem®
          References
          ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.
          Product Information
          ATP CompetitiveY
          FormLiquid
          FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
          Hill FormulaC₂₃H₁₈N₄O₃
          Chemical formulaC₂₃H₁₈N₄O₃
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCK1, CK1d
          Primary Target IC<sub>50</sub>0.2 µM, 0.3 µM against CK1, CK1d, respectively
          Purity≥95% by HPLC
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218705

          References

          Reference overview
          Rena, G., et al. 2004. EMBO Reports 5, 60.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-June-2008 RFH
          DescriptionA cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
          FormLiquid
          FormulationA 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
          Intert gas (Yes/No) Packaged under inert gas
          Concentration Label Please refer to vial label for lot-specific concentration
          Chemical formulaC₂₃H₁₈N₄O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
          Toxicity Irritant
          ReferencesRena, G., et al. 2004. EMBO Reports 5, 60.