203293 | InSolution™ Bisindolylmaleimide I - CAS 133052-90-1 - Calbiochem

203293
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₄N₄O₂ 133052-90-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203293-1ML
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          Glass bottle 1 ml
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          Description
          Catalogue Number203293
          Brand Family Calbiochem®
          Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850
          References
          ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
          Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
          Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Product Information
          CAS number133052-90-1
          ATP CompetitiveY
          FormLiquid
          FormulationA 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
          Hill FormulaC₂₅H₂₄N₄O₂
          Chemical formulaC₂₅H₂₄N₄O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target K<sub>i</sub>10 nM against PKC
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203293

          References

          Reference overview
          Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
          Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
          Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

          Citations

          Title
        • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
        • Xiaohua Jiang, et al. (2005) Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arteriosclerosis, Thrombosis, and Vascular Biology in press,.
        • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
        • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-May-2008 RFH
          Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850
          DescriptionA highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µM). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
          FormLiquid
          FormulationA 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number133052-90-1
          Chemical formulaC₂₅H₂₄N₄O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
          Gekeler, V., et al. 1996. Br. J. Cancer 74, 897.
          Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93.
          Muid, R.E., et al. 1991. FEBS Lett. 293, 160.
          Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
          Citation
        • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
        • Xiaohua Jiang, et al. (2005) Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arteriosclerosis, Thrombosis, and Vascular Biology in press,.
        • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
        • Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.