197334 InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem

197334
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₄₂H₄₅ClN₆O₅S₂
      Description
      Catalogue Number197334
      Brand Family Calbiochem®
      Synonyms(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide
      References
      ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
      Oltersdorf, T., et al. 2005. Nature 435, 677.
      Product Information
      FormLiquid
      FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
      Hill FormulaC₄₂H₄₅ClN₆O₅S₂
      Chemical formulaC₄₂H₄₅ClN₆O₅S₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetBcl-2 family members
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem Certificates of Analysis

      TitleLot Number
      197334

      References

      Reference overview
      Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
      Oltersdorf, T., et al. 2005. Nature 435, 677.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      Synonyms(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide
      DescriptionA cell-permeable nitrophenylsulfonylbenzamide compound that is shown to bind anti-apoptotic Bcl-2 family members Bcl-2, Bcl-XL, and Bcl-w with high affinity (Ki ≤1 nM) and serves as a nonpeptidyl alternative to Bad-derived BH3 peptide (Cat. No. 197220) in preventing the binding and inhibition of the pro- apoptotic by the anti-apoptotic Bcl-2 family proteins. ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC50 ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.). Application of ABT-737 is also demonstrated to significantly reduce the disease severity in several murine models of autoimmunity.
      FormLiquid
      FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₂H₄₅ClN₆O₅S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
      Toxicity Standard Handling
      ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
      Oltersdorf, T., et al. 2005. Nature 435, 677.