508409 | InSolution™ Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem

508409
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₅H₅₈O₉ 88899-55-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08409.0001
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          Glass bottle 15 μg
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          Description
          Catalogue Number508409
          Brand Family Calbiochem®
          SynonymsBafilomycin A1, ≥97% by HPLC InSolution
          References
          ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
          Product Information
          CAS number88899-55-2
          FormLiquid
          FormulationA 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
          Hill FormulaC₃₅H₅₈O₉
          Chemical formulaC₃₅H₅₈O₉
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Primary Targetvacuolar-type H+-ATPase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-April-2014 JSW
          SynonymsBafilomycin A1, ≥97% by HPLC InSolution
          DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
          FormLiquid
          FormulationA 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number88899-55-2
          Chemical formulaC₃₅H₅₈O₉
          Purity≥97% by HPLC
          Storage ≤ -70°C
          Hygroscopic
          Protect from light
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.
          Toxicity Standard Handling
          ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
          Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
          Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
          Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
          Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
          Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
          Drose, S., et al. 1993. Biochemistry 32, 3902.
          Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
          Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.