171264 | InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

171264
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₂₅N₅O 866405-64-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      171264-2MG
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          Glass bottle 2 mg
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          Description
          OverviewA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
          Catalogue Number171264
          Brand Family Calbiochem®
          Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
          References
          ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Product Information
          CAS number866405-64-3
          FormLiquid
          FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
          Hill FormulaC₂₄H₂₅N₅O
          Chemical formulaC₂₄H₂₅N₅O
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          171264

          References

          Reference overview
          Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2012 JSW
          Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
          DescriptionA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice.
          FormLiquid
          FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number866405-64-3
          Chemical formulaC₂₄H₂₅N₅O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
          ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
          Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
          Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
          Inoki, K., et al. 2003. Cell 115, 577.
          Fryer, L.G., 2002. FEBS Lett. 531, 189.
          Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.