531237 IRAK4 Inhibitor, Compound 26 - Calbiochem

531237
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₅H₂₇N₅O₂

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.31237.0001
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          Glass bottle 10 mg
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          Description
          OverviewA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531237
          Brand Family Calbiochem®
          SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
          References
          ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.
          Product Information
          FormPale yellow powder
          Hill FormulaC₂₅H₂₇N₅O₂
          Chemical formulaC₂₅H₂₇N₅O₂
          ReversibleY
          Applications
          Biological Information
          Primary TargetIRAK4
          Primary Target IC<sub>50</sub>94 pM
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          IRAK4 Inhibitor, Compound 26 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Tumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-August-2017 JSW
          SynonymsInterleukin-1 Receptor Associated Kinase 4 Inhibitor
          DescriptionA cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).
          FormPale yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₂₇N₅O₂
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.