407621 | IL-2Rα Antagonist - CAS 1217448-66-2 - Calbiochem

407621
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₆H₃₀N₄O₃ • CF₃CO₂H 1217448-66-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407621-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
          Catalogue Number407621
          Brand Family Calbiochem®
          Synonyms(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
          References
          ReferencesEmerson, S.D., et al. 2003. Protein Science 12, 811.
          Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.
          Product Information
          CAS number1217448-66-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
          Chemical formulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInhibitor of the IL-2/IL-2Rα interaction
          Primary Target IC<sub>50</sub>3 µM against IL-2/IL-2Rα interaction
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407621

          References

          Reference overview
          Emerson, S.D., et al. 2003. Protein Science 12, 811.
          Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-April-2011 RFH
          Synonyms(R)-N-(2-(1-(Aminoiminomethyl)-3-piperidinyl)-1-oxoethyl)-4-(phenylethynyl)-L-phenylalanine methyl ester, trifluoroacetate, Ro26-4550
          DescriptionA non-peptidyl acylphenylalanine compound that binds to IL-2 and acts as a competitive inhibitor of the IL-2/IL-2Rα interaction (IC50 = 3 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1217448-66-2
          Chemical formulaC₂₆H₃₀N₄O₃ • CF₃CO₂H
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (28 mg/ml) or Ethanol (2 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesEmerson, S.D., et al. 2003. Protein Science 12, 811.
          Tilley, J.W., et al. 1997. J. Am. Chem. Soc. 119, 7589.