505275 ICI 118551 Hydrochloride - CAS 72795-19-8 - Calbiochem

505275
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₂₇NO₂ • HCl 72795-19-8

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05275.0001
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          Glass bottle 10 mg
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          Description
          OverviewA highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively).
          Catalogue Number505275
          Brand Family Calbiochem®
          Synonyms (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
          References
          ReferencesBilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
          Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
          Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
          Strosberg, A., et al. 1996. TiPS 17, 373.
          Product Information
          CAS number72795-19-8
          FormWhite solid
          Hill FormulaC₁₇H₂₇NO₂ • HCl
          Chemical formulaC₁₇H₂₇NO₂ • HCl
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target→2 adrenergic receptors
          Primary Target K<sub>i</sub>1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
          Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
          Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
          Strosberg, A., et al. 1996. TiPS 17, 373.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-December-2013 JSW
          Synonyms (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride
          DescriptionA highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number72795-19-8
          Chemical formulaC₁₇H₂₇NO₂ • HCl
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBilski, A., et al. 1983. J. Cardiovasc. Pharmacol. 5, 430.
          Cook, S. et al. 1993. Br. J .Pharmacol. 109, 1140.
          Ten Berge, R., et al. 1995. Eur. J. Pharmacol. 275, 199.
          Strosberg, A., et al. 1996. TiPS 17, 373.