401478 | IκB Kinase Inactive Control Peptide, Cell-Permeable - Calbiochem

401478
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₃₈H₂₂₉N₃₇O₄₃S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401478-1MG
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      Stocked 
      Discontinued
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          Plastic ampoule 1 mg
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          Description
          OverviewAn inactive control for IκB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IκB (Ser32→Ala and Ser36→Ala) fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
          Catalogue Number401478
          Brand Family Calbiochem®
          SynonymsAc-AAVALLPAVLLALLAPDDRHDAGLDAMKDE-NH₂
          References
          ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.
          Product Information
          ATP CompetitiveN
          FormOff-white to white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₃₈H₂₂₉N₃₇O₄₃S
          Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₃S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary TargetAn inactive control for IκB Kinase Inhibitor Peptide
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401478

          References

          Reference overview
          Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          SynonymsAc-AAVALLPAVLLALLAPDDRHDAGLDAMKDE-NH₂
          DescriptionAn inactive control for IkB Kinase Inhibitor Peptide (Cat. No. 401477). A 14-amino acid peptide corresponding to the mutated recognition sequence of IkB (Ser32 → Ala and Ser36 → Ala), linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Does not have any inhibitory effect on LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells at 50 µg/ml.
          FormOff-white to white solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₃₈H₂₂₉N₃₇O₄₃S
          Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ala-Gly-Leu-Asp-Ala-Met-Lys-Asp-Glu-NH₂
          Purity≥97% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSwaroop, N., et al. 2001. Pharm. Res. 18, 1631.
          Traenckner, E.B., et al. 1995. EMBO J. 14, 2876.