401011 Hypothemycin - CAS 76958-67-3 - Calbiochem

401011
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₂O₈ 76958-67-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401011-500UG
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          500 μg
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          Description
          OverviewA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
          Catalogue Number401011
          Brand Family Calbiochem®
          SynonymsNSC 354462
          References
          ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
          Solit, D.B., et al. 2006. Nature 439, 358.
          Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
          Product Information
          CAS number76958-67-3
          FormLyophilized solid
          Hill FormulaC₁₉H₂₂O₈
          Chemical formulaC₁₉H₂₂O₈
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401011

          References

          Reference overview
          Schirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
          Solit, D.B., et al. 2006. Nature 439, 358.
          Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision30-August-2010 RFH
          SynonymsNSC 354462
          DescriptionA cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCµ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
          FormLyophilized solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number76958-67-3
          Chemical formulaC₁₉H₂₂O₈
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
          Solit, D.B., et al. 2006. Nature 439, 358.
          Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.